End-to-end VHH design API

NanobodyAI

From target sequence to validated VHH candidate in 45 minutes. Powered by AlphaFold 3, ESMFold, ESM-2, and molecular dynamics.

500 candidates → top 10 validatedEpitope-targeted designDevelopability scored
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Built on validated pipeline · 1 design/month free · Cancel anytime

Everything you need to design a VHH

From target sequence to gBlock-ready DNA. No AI/ML expertise required.

AlphaFold 3 powered

Each candidate validated against your target with AlphaFold 3 multimer. Get iPTM scores and binding poses in minutes, not weeks.

Full developability

Aggrescan3D, CamSol, NetMHCIIpan, and Tm prediction — built into every result. Avoid liabilities before you produce.

Production-ready output

Codon-optimized DNA, gBlock sequences with cloning sites, expression predictions. Ready to order from IDT or Twist.

Epitope-targeted

Specify exact target residues to block. Steric clash analysis ensures your VHH disrupts the right interface.

Multivalent design

One-click trivalent constructs for avidity boost (100-1000× Kd improvement). Validated against trimeric targets like CD74 or IL-15.

Full API + dashboard

Programmatic access via REST, or interactive design in browser. Track jobs, download structures, share with your team.

6 steps · 45 minutes total

The pipeline

What used to take a wet-lab team 6 months runs in your browser in under an hour.

1

Submit your target

Sequence + optional epitope residues

Instant
2

Library generation

500 VHH candidates with biased random CDR3 + composition filters

~1 min
3

ESM-2 PLL ranking

Naturalness scoring, filter top 50 candidates

~5 min
4

ESMFold structures

Predict 3D structure of top 50, filter by pLDDT >70

~15 min
5

AlphaFold 3 docking

Multimer prediction of top 10 vs target, rank by iPTM

~20 min
6

Developability + DNA

Aggrescan3D, NetMHCIIpan, Tm prediction, codon-opt gBlock

~2 min

Output: 10 ranked VHH candidates

Each with structure (PDB), affinity prediction, developability scores, and ready-to-order DNA

Simple, transparent pricing

Start free. Upgrade when you scale. Cancel anytime.

Free

Try the platform

€0/mo
1 design / month
  • Full pipeline (500 candidates → top 10)
  • AlphaFold 3 validation
  • Developability scores
  • Codon-optimized DNA
  • Community support
Start free

Starter

For small labs and academics

€49/mo
10 designs / month
  • Everything in Free
  • Priority queue (faster runs)
  • Email support (24h)
  • Dashboard analytics
  • API access (rate-limited)
Choose Starter
Most popular

Pro

For biotechs and research groups

€299/mo
100 designs / month
  • Everything in Starter
  • Trivalent constructs
  • Humanization suggestions
  • Full API access (no rate-limit)
  • Webhook callbacks
  • Priority support (4h)
Choose Pro

Enterprise

For pharma and large biotech

Custom
Unlimited designs
  • Everything in Pro
  • On-premise deployment option
  • Custom integration
  • Dedicated account manager
  • SLA + uptime guarantees
  • Compliance (SOC2, GxP-ready)
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All plans include AlphaFold 3 validation, ESMFold structures, and developability analysis. Unused credits roll over up to 3 months on Pro and Team plans.

Design your first VHH today

Sign up free and get 1 design / month. No credit card required. Upgrade only when you need more.

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Trusted by researchers · Built on validated wet-lab cases · Open API